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MerkenPsychedelic-Assisted Therapy: Applications in Mental Health
11.12.2022
The United States is experiencing a mental health crisis and psychedelics (ketamine, LSD, MDMA, psilocybin) have emerged as a potential new drug class to add to the treatment armamentarium. Approximately 21% of adults in the US have experienced mental illness in the last year.1 Major depressive disorder alone accounts for $326 billion in economic burden annually,2 with a national average of 22% of adults taking psychotropic medications in March 2022.3
The most commonly available medications for mental health — serotonin-norepinephrine reuptake inhibitors (SNRIs), selective serotonin reuptake inhibitors (SSRIs), tricyclic antidepressants, antipsychotic agents — are not always effective in achieving complete remission of symptoms or restoring function. In fact, despite an increased utilization of prescription medications for mental health, the overall rate of suicide has climbed by 35% over the last 2 decades.4 In comparison to the scope and scale of the mental health crisis in the US, the current prescription drug development pipeline is incredibly small.5
Psychedelics as a Drug Class
Initially researched in the 1940s, psychedelics are reemerging as one potential solution in the treatment of depression, anxiety, post-traumatic stress disorder (PTSD), and substance use disorders.5 No widely agreed-upon definition of psychedelic exists, however, drugs with this classification generally are thought to have fundamental properties related to producing hallucinations, as well as providing an experience that expands consciousness.6
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